From Health Facts
Latest Edit: Hector 2014-03-21 (EDT)
|See Also||Lab Tests|
- Alpha-1 antitrypsin, or AAT inactivates endoproteases (protein catabolic enzymes that are released in the body by degenerating and dying cells), such as trypsin and neutrophil elastase.
- Deficiencies of AAT can be genetic or acquired, where acquired deficiencies can occur in patients with protein-deficiency syndromes (e.g. malnutrition, liver disease, nephrotic syndrome, neonatal respiratory distress syndrome).
- The major clinical symptoms of AAT deficiency include progressive dyspnea with minimal coughing. Chronic bronchitis and bronchiectasis can be seen in those with AAT deficiency who smoke.
- No fasting required.
- Factors which can cause increased levels
- Serum levels of AAT can double during pregnancy.
- Drugs: Oral contraceptives
- Factors which can cause decreased levels
- None noted
High levels indicate:
Low levels indicate:
- Early onset of emphysema (adults)
- Neonatal respiratory distress syndrome
- Low serum proteins
- Pagana Kathleen D, Pagana Timothy J (2006) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby.