From Health Facts
Latest Edit: Hector 2014-03-21 (EDT)
|See Also||Lab Tests|
- Androstenediones (ADs, DHEA, and its sulfuric ester, DHEA S) are precursors of testosterone and estrone and are produced in the gonads and the adrenal glands.
- ACTH secretion is stimulated by the lack of cortisol, which in turn stimulates the adrenal secretion of androstenediones.
- As ACTH increases the level of ADs, these hormones are converted into a high level of testosterone by the peripheral tissues.
- ADs are found to be elevated in cases of hirusitism and virilization.
- Fasting is preferable.
- Factors which can cause increased levels
- Drugs: corticotropin, clomiphene, and metyrapone
- Factors which can cause decreased levels
- Drugs: Steroids
High levels indicate:
- Adrenal tumor
- Congenital adrenal hyperplasia
- Ectopic ACTH-producing tumors
- Cushing disease
- Cushing syndrome
- Stein-Leventhal syndrome
- Ovarian sex cord tumor
Low levels indicate:
- Primary or secondary adrenal insufficiency
- Ovarian failure
- Pagana Kathleen D, Pagana Timothy J (2006) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby.