Androstenediones

Latest Edit: Hector 2014-03-21 (EDT)

See Also	Lab Tests

This test is used for evaluating virilizing syndromes such as polycystic ovarian syndrome, adrenal hyperplasia, and cushing disease to name a few.

Discussion

• Androstenediones (ADs, DHEA, and its sulfuric ester, DHEA S) are precursors of testosterone and estrone and are produced in the gonads and the adrenal glands.
• ACTH secretion is stimulated by the lack of cortisol, which in turn stimulates the adrenal secretion of androstenediones.
• As ACTH increases the level of ADs, these hormones are converted into a high level of testosterone by the peripheral tissues.
• ADs are found to be elevated in cases of hirusitism and virilization.

Patient Preparation

• Fasting is preferable.

• Factors which can cause increased levels

• Drugs: corticotropin, clomiphene, and metyrapone

• Factors which can cause decreased levels

• Drugs: Steroids

Clinical Implications

High levels indicate:

• Adrenal tumor
• Congenital adrenal hyperplasia
• Ectopic ACTH-producing tumors
• Cushing disease
• Cushing syndrome
• Stein-Leventhal syndrome
• Ovarian sex cord tumor

Low levels indicate:

• Primary or secondary adrenal insufficiency
• Ovarian failure
• Oophorectomy

Associated Tests

• Testosterone, Estradiol, Cortisol