Apolipoprotein A1 is greater predictor for lower incidence of cardiovascular disease than HDL alone. Apolipoprotein A1 activates the enzymes that load cholesterol from the tissues into HDL and allows HDL to effectively get rid of the excess cholesterol at the tissue level. Deficiencies in apolipoprotein A1 are associated with increased risk of cardiovascular disease as the cholesterol is not transported back to the liver.
- Apolipoprotein A1 is often ordered if there is a family history of myocardial infarction in young men in order to determine a person's risk.
- Apolipoprotein B have been found to be associated with an increased risk of atherosclerotic coronary artery disease.
- Patient must fast for 12- 14 hours before testing. Water is permitted.
- Smoking is prohibited.
- Factors which can cause increased levels:
- physical exercise
- Drugs: carbamazepine, estrogens, ehtanol, lovastatin, niacin, oral contraceptives, phenobarbital, pravastatin, and simvastatin
- Factors which can cause decreased levels:
- High levels indicate:
- lowered incidence of cardiovascular disease
- Low levels indicate:
- Pagana Kathleen D, Pagana Timothy J, (1998) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby, Inc
- Weatherby Dicken, Ferguson Scott (2002) Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain