Bence Jones protein Urine Test

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Latest Edit: Hector 2014-03-24 (EDT)

See Also Lab Tests

Bence Jones proteins are immunoglobulin light chains found in 75% of patients with multiple myeloma. This protein is made by the plasma cells in these patients. Due to the size of this protein, it is easily filtrated by the kidneys and excreted into the urine. Since Bence Jones proteins are rapidly cleared from the blood by the kidneys, it is generally difficult to detect in the blood. [1],[2]


  • Bence Jones proteins in the urine, particularly at high levels, indicates multiple myeloma
  • This test is therefore used to detect and monitor the treatment and clinical course of multiple myeloma and other similar diseases

Patient Preparation

Interfering Factors

  • Factors which can cause iccreased levels:
  • None noted
  • Factors which can cause decreased levels:
  • Dilute urine

Clinical Implications


High levels indicate:

  • Multiple myeloma (plasmacytoma)
  • Chronic lymphocytic leukemia
  • Lymphoma
  • Metastatic colon, breast, lung, or prostate cancer
  • Amyloidosis
  • Waldenstrom's macroglobulinemia

Low levels indicate:

  • None noted

Associated Tests


  1. Pagana Kathleen D., Pagana Timothy J., Mosby's Manual of Diagnostic and Laboratory Tests, Mosby, Inc
  2. Weatherby Dicken, Ferguson Scott. Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain