Cortisol Urine Test

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Latest Edit: Hector 2014-03-24 (EDT)

See Also Lab Tests

Cortisol is a glucocorticoid released from the adrenal cortex. This hormone affects the metabolism of carbohydrates, proteins, and fats. It also significantly affects glucose serum levels. Cortisol can increase glucose by stimulating gluconeogenesis from glucose stores as well as inhibit the effect of insulin, thereby inhibiting glucose transport into the cells. [1],[2]


  • This test is performed in patients with suspected hypo- or hyperfunction of the adrenal gland.
  • Elevated urine levels indicate elevated serum cortisol levels.

Patient Preparation

Interfering Factors

  • Factors which can cause increased levels:
  • Factors which can cause decreased levels:
  • none noted
  • Drugs: dexamethasone, ethacrynic acid, ketoconazole, and thiazides

Clinical Implications


High levels indicate:

Low levels indicate:

Associated Tests


  1. Pagana Kathleen D., Pagana Timothy J., Mosby's Manual of Diagnostic and Laboratory Tests, Mosby, Inc
  2. Weatherby Dicken, Ferguson Scott. Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain