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Latest Edit: Hector 2014-03-24 (EDT)

See Also Lab Tests

This test is specific and used to confirm disseminated intravascular coagulation.[1]


  • D-dimer is a fibrin degradation fragment that is made through fibrinolysis
  • D-dimer assay is a highly specific measurement of the amount of fibrin degradation that occurs
  • Although the D-dimer assay is more specific than the FDP (fragment degradation product), it is less sensitive. Therefore, combining the FDP and D-dimer test provides a more sensitive and specific test for DIC.
  • Levels of D-dimer can increase when a fibrin clot is lysed by thrombolytic therapy or with thrombotic problems such as deep-vein thrombosis or pumonary embolism.

Patient Preparation

  • No fasting required.

Clinical Implications

High levels indicate:

  • Disseminated intravascular coagulation
  • Intermittent Claudication
  • Primary fibrinolysis
  • During thrombolytic or defibrination therapy
  • Deep-vein thrombosis
  • Pulmonary embolism
  • Arterial thromboembolism
  • Vaso-occlusive crisis of sickle cell anemia
  • Pregnancy
  • Malignancy
  • Surgery

Associated Tests

  • Bleeding time, Thrombin time, Prothrombin Time, Coagulating factor concentration, Partial thromboplastin time, Fibrin degradation product, Euglobulin lysis time


  1. Pagana Kathleen D, Pagana Timothy J (2006) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby.