Factor V-Leiden

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Latest Edit: Hector 2014-03-24 (EDT)

See Also Lab Tests

The Factor V-Leiden test is used to diagnose factor V-Leiden thrombophilia.[1]


  • Factor V is an important factor in normal hemostasis.
  • Factor V-Leiden refers to an abnormal form of factor V in which a genetic mutation causes a single amino acid replacement.
  • Individuals heterozygous for the factor V-Leiden mutation have a slightly increased risk for venous thrombosis. Whereas homozygous individuals have a greater thrombotic risk (e.g. deep vein thrombosis, arterial thrombosis, or pulmonary embolism)
  • Testing usually begins with a coagulation screening test which is used to identify resistance of activated protein C (APC) on normal hemostasis.

Patient Preparation

  • No fasting required.

Clinical Implications

High levels indicate:

  • APC resistance
  • FVL genetic mutation

Associated Tests


  1. Pagana Kathleen D, Pagana Timothy J (2006) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby.