From Health Facts
Latest Edit: Hector 2014-03-24 (EDT)
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The Factor V-Leiden test is used to diagnose factor V-Leiden thrombophilia.
- Factor V is an important factor in normal hemostasis.
- Factor V-Leiden refers to an abnormal form of factor V in which a genetic mutation causes a single amino acid replacement.
- Individuals heterozygous for the factor V-Leiden mutation have a slightly increased risk for venous thrombosis. Whereas homozygous individuals have a greater thrombotic risk (e.g. deep vein thrombosis, arterial thrombosis, or pulmonary embolism)
- Testing usually begins with a coagulation screening test which is used to identify resistance of activated protein C (APC) on normal hemostasis.
- No fasting required.
High levels indicate:
- APC resistance
- FVL genetic mutation
- Protein C, Protein S, Partial thromboplastin time
- Pagana Kathleen D, Pagana Timothy J (2006) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby.