Prostate Specific Antigen (PSA)

Latest Edit: Hector 2014-03-24 (EDT)

See Also	Lab Tests

Prostate specific antigen or PSA is a glycoprotein (part carbohydrate, part protein) found in the cytoplasm of prostatic epithelial cells. Although this antigen can be detected in all males, the levels of PSA are greatly increased in patients with prostate cancer.

Article	Interpreting and Using the PSA Test,2010 November NDNR

Discussion

• This test is used as a screening method for early detection of prostatic cancer and to monitor the disease after treatment.
• PSA and prostatic acid phosphatase or PAP levels can be found to be minimally elevated in patients with benign prostatic hypertrophy (BPH) and prostatitis

Patient Preparation

• No fasting is required

• Factors which can cause increased levels:

• Rectal examinations, prostatic manipulation by biopsy or transurethral resection of the prostate (TURP)

• Factors which can cause decreased levels:

• None noted

Clinical Implications

High levels indicate:

• Prostate cancer
• BPH
• Prostatitis

Associated Tests

• Prostatic acid phosphatase (PAP), PSA ratio