Vitamin B12 Blood Test

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Latest Edit: Hector 2014-03-21 (EDT)

See Also Lab Tests

This test is used to help diagnose one cause of anemia or neuropathy, to evaluate nutritional status in some people, and to monitor the effectiveness of treatment for vitamin B12 or folate deficiency.[1], [2]


  • B12 and folate are both make up the B complex of vitamins and are necessary for normal red blood cell formation, tissue and cellular repaid, and DNA synthesis.
  • These tests measure the levels of folate and vitamin B12 in the liquid portion of the blood, the serum, or plasma, in order to detect deficiencies.

Patient Preparation

  • Fasting for 6-8 hours before sample collection may be required.

Clinical Implications

High levels indicate:

  • Myeloproliferative disorder
  • Diabetes
  • Heart failure
  • Obesity
  • AIDS
  • Severe liver disease

Low levels indicate:

Associated Tests


  1. Pagana Kathleen D, Pagana Timothy J (2006) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby.
  2. Weatherby Dicken, Ferguson Scott (2002) Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain.