Bone Health Panel

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Latest Edit: Hector 2014-03-24 (EDT)

See Also Lab Tests

The best approach to osteoporosis is prevention, especially in patients who are high risk. A Bone Health Panel is a valuable way to assess for osteoporosis risk and as a preliminary screening tool for other bone-related conditions.[1]


  • Peak bone mass occurs between 20 to 30 years of age. After that total bone mass gradually declines in both men and women.
  • Some women experience an increased rate of bone loss in the early post-menopausal years.
  • Total bone density is based on the difference between the levels of osteoclasts (which erode bone surfaces and release collagen by-products into circulation) and the level of osteoblasts (which are bone-forming cells that secrete bone matrix proteins and hormones that help in the remodeling and building of bone).
  • Bone health is influenced by the level of estrogens, progesterone, testosterone, cortisol, FSH and DHEA.
  • The following are some of the known bone resorption and bone formation bone markers: C-telopeptide, N-telopeptide, Deoxypyridinoline, Pyridinium Crosslinks, Tartrate-resistant acid phophatase

What is Measured?

The following hormones are often included in a Bone Health Panel:

Bone formation blood tests can provide an indication of the rate of resorption and/or formation of bone. What is commonly measured includes:

Tests that measure bone loss may include;

  • C-telopeptide
  • Deoxypryidinoline (DPD)
  • Pyridinium Crosslinks
  • Tartrate-resistant acid phosphatase (TRAP) 5b


A Bone Health Panel can be used as a preliminary screening tool for the following conditions:

  • those at high risk of osteoporosis
  • monitoring osteoporosis treatment
  • to assess hip-fracture risk
  • estrogen-deficient women
  • prior to long-term glucocorticoid therapy
  • metabolic bone diseases
  • rheumatoid arthritis and other connective tissue disease
  • Paget’s disease.
  • bone malignancies