From Health Facts
Latest Edit: Hector 2014-03-24 (EDT)
|See Also||Lab Tests|
Follicle-stimulating hormone (FSH) is used to evaluate pituitary function, especially as it relates to fertility issues, gonadal failure, maturation concerns or pituitary tumors.
- FSH is made by the pituitary gland. Control of FSH production is a complex system involving hormones produced by the ovaries or testes, the pituitary and the hypothalamus.
- In women, FSH stimulates the growth and maturation of eggs (follicles) in the ovaries during the follicular phase of the menstrual cycle.
- In men, FSH stimulates the testes to produce mature sperm and also promotes the production of androgen binding proteins.
- Indications for measuring FSH include:
- No fasting required.
- FSH can be measured in blood or urine.
- Factors which can cause increased levels
- radiation therapy
- Medications such as cimetidine, digitalis, levodopa, anticonvulsants, clomiphene, naloxone, and spironalactone
- Factors which can cause decreased levels
High levels indicate:
- primary ovarian failure
- primary testicular failure
- failure to develop gonads
- Klinefelters syndrome
- viral infection (mumps)
- Autoimmune disease
- germ cell tumor
Low levels indicate:
- pituitary failure
- hypothalamic failure
- secondary ovarian failure
- increased risk of Ovarian Cancer
- Pagana Kathleen D, Pagana Timothy J (2006) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby.