Bence Jones protein Urine Test
From Health Facts
Latest Edit: Hector 2014-03-24 (EDT)
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Bence Jones proteins are immunoglobulin light chains found in 75% of patients with multiple myeloma. This protein is made by the plasma cells in these patients. Due to the size of this protein, it is easily filtrated by the kidneys and excreted into the urine. Since Bence Jones proteins are rapidly cleared from the blood by the kidneys, it is generally difficult to detect in the blood. [1],[2]
Contents
Discussion
- Bence Jones proteins in the urine, particularly at high levels, indicates multiple myeloma
- This test is therefore used to detect and monitor the treatment and clinical course of multiple myeloma and other similar diseases
Patient Preparation
Interfering Factors
- Factors which can cause iccreased levels:
- None noted
- Factors which can cause decreased levels:
- Dilute urine
Clinical Implications
Ranges
High levels indicate:
- Multiple myeloma (plasmacytoma)
- Chronic lymphocytic leukemia
- Lymphoma
- Metastatic colon, breast, lung, or prostate cancer
- Amyloidosis
- Waldenstrom's macroglobulinemia
Low levels indicate:
- None noted
Associated Tests
References
- ↑ Pagana Kathleen D., Pagana Timothy J., Mosby's Manual of Diagnostic and Laboratory Tests, Mosby, Inc
- ↑ Weatherby Dicken, Ferguson Scott. Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain
