From Health Facts
Latest Edit: Hector 2014-03-24 (EDT)
|See Also||Lab Tests|
- PTT evaluates factors I (fibrinogen), II (prothrombin), V, VIII, IX, X, XI, XII involved in clotting.
- Nearly all hemostatic abnormalities can be recognized when the PPT is combined with the prothrombin time.
- On the other hand, heparin has been found to inactivate prothrombin (factor II) and to prevent the formation of thromboplastin.
- No fasting required.
- Factors which can cause increased levels
- Drugs: antihistamines, ascorbic acid, chlorpromazine, heparin, and salicylates.
- Factors which can cause decreased levels
- None noted
High levels indicate:
- Congenital clotting factor deficiencies (e.g. von Willebrand disease, hemophilia, hypofibrinogenemia)
- Cirrhosis of the liver
- Vitamin K deficiency
- Diseeminated intravascular coagulation (DIC)
- Heparin administration
- Coumarin administration
Low levels indicate:
- Early stages of DIC
- Extensive cancer
- Bleeding time, Thrombin time, Prothrombin Time, Coagulating Factor Concentration
- Pagana Kathleen D, Pagana Timothy J (2006) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby.
- Weatherby Dicken, Ferguson Scott (2002) Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain.