Prostate Specific Antigen (PSA)

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Latest Edit: Hector 2014-03-24 (EDT)

See Also Lab Tests

Prostate specific antigen or PSA is a glycoprotein (part carbohydrate, part protein) found in the cytoplasm of prostatic epithelial cells. Although this antigen can be detected in all males, the levels of PSA are greatly increased in patients with prostate cancer.[1]

Article Interpreting and Using the PSA Test,2010 November NDNR


Patient Preparation

  • No fasting is required
  • Factors which can cause increased levels:
  • Rectal examinations, prostatic manipulation by biopsy or transurethral resection of the prostate (TURP)
  • Factors which can cause decreased levels:
  • None noted

Clinical Implications

High levels indicate:

Associated Tests

  • Prostatic acid phosphatase (PAP), PSA ratio


  1. Pagana Kathleen D, Pagana Timothy J, (1998) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby, Inc