From Health Facts
Total serum globulin consists of individual globulin fractions called alpha 1, alpha 2, beta and gamma fractions. Thus the total globulin level is greatly affected by increases or decreases in one or more of these fractions. They are produced in the liver, the retoculoendothelial system, and other tissues. The function of globulins is to transport substances in the blood. They also make up the antibody system, clotting proteins and complement.
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- As inflammatory, degenerative, or infectious processes are associated with an increased production of antibodies, measuring the total serum globulin is a useful way to assess these processes.
- Total globulin, along with subjective indicators, can also help to confirm an underlying digestive problem of an inflammatory or infectious nature.
- Protein electrophoresis is a method widely used to identify the specific globulin that is responsible for the total serum globulin increase or decrease.
- No specific preparation is required.
- Factors which can cause increased levels
- None noted
- Factors which can cause decreased levels
- None noted
Ranges: The following are the reference ranges for this lab. However, lab ranges can vary by laboratory and country. 
|Standard U.S. Units||Standard International Units|
|Conventional Laboratory Range||2.0-3.9 g/dL||20-39 g/L|
|Optimal Range||2.4-2.8 g/dL||24-28 g/L|
|Alarm Ranges||< 2.0 or > 3.5 g/dL||< 20 or > 35 g/L|
High levels indicate:
- Liver damage/infections
- Oxidative stress and free radical activity
- Heavy metal/ chemical toxicity
- Immune Activation
- Other conditions: parasites (intestinal or liver), auto-immune processes, exogenous hormone administration, rheumatoid arthritis, tissue destruction, acute viral/bacterial infections, Hepatitis
Low levels indicate:
- Digestive dysfunction
- Immune insufficiency
- Other conditions: anemia, chronic viral/bacterial infections, liver disease
- Albumin, A/G ratio, total protein, protein electrophoresis, Gastrin, liver enzymes, sedimentation rate, WBC and differential, alpha 1 Glycoproteins, CEA, and other tests used to confirm neoplasm
- ↑ Pagana Kathleen D, Pagana Timothy J, (1998) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby, Inc
- ↑ Weatherby Dicken., Ferguson Scott. Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain