Albumin/Globulin Ratio

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Latest Edit: Hector 2014-3-21 (EDT)

See Also Lab Tests

This ratio is dependent on the albumin and total globulin levels and is normally used as a rough guide, due to the variability in albumin and globulin levels. The globulin portion of the ratio is considered to have the most impact and is therefore the most clinically relevant.[1], [2]


Contents

Discussion

  • An increased ratio can be attributed to either a decreased globulin or an increased albumin level, which occurs with dehydration.
  • This test is done to:
  • investigate inflammatory and/or immunological disturbances
  • to ascertain digestive sufficiency

Patient Preparation

  • No fasting is required
  • Factors which can cause increased levels
  • Factors which can cause decreased levels
  • Normal during pregnancy, Excessive hemolysis when sample is taken while lying down.

Clinical Implications

Ranges: The following are the reference ranges for this lab. However, lab ranges can vary by laboratory and country. [2]

Standard U.S. Units Standard International Units
Conventional Laboratory Range 1.1-2.5 1.1-2.5
Optimal Range 1.5-2.0 1.5-2.0
Alarm Ranges < 1.0 < 1.0

High levels indicate

Low levels indicate

  • Liver dysfunction
  • Immune activation
  • Other conditions: blood maybe too thin (rule out chronic aspirin use, unnecessary blood thinners)

Associated Tests

References

  1. Pagana Kathleen D, Pagana Timothy J (1998) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby, Inc.
  2. 2.0 2.1 Weatherby Dicken, Ferguson Scott (2002) Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain.
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