Anti-ds DNA

Latest Edit: Hector 2014-03-21 (EDT)

See Also	Lab Tests

This test is used for the diagnosis and follow-up of systemic lupus erythematosus (SLE).

Discussion

• Anti-ds antibody is a type of anti-DNA antibody, which itself is a subtype of the antinuclear antibodies (ANAs).
• Anti-DNA antibody is found in roughly 65% to 80% of patients with active SLE, and rarely in patients with other diseases.
• Low to intermediate levels of this antibody may be found in patients with other rheumatic diseases.
• Near-negative values can be seen in patients with dormant SLE.

Patient Preparation

• No fasting required.

• Factors which can cause increased levels

• Drugs:hydralazine and procainamide

• Factors which can cause decreased levels

• None noted

Clinical Implications

High levels indicate:

• Systemic Lupus Erythematosus
• Other autoimmune diseases, such as rheumatic fever
• Chronic hepatitis
• Infectious mononucleosis
• Biliary cirrhosis

Associated Tests

• Antinuclear antibody