Systemic Lupus Erythematosus
From Health Facts
Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect the skin, joints, kidneys, brain, and other organs.
|Causes||Infections, Environmental Toxins, Stress, Prescription Medications|
|See Also||Musculoskeletal Conditions, Autoimmune Disease|
|Books||Books on Infections, Allergies, Intolerances|
|Articles||Articles on Infections / Allergies / Sensitivities|
In order to stimulate the innate ability of the body to heal the causes of disease must be identified and addressed. With SLE environmental factors are primary, but other factors also need to be considered.
- Volatile organic compounds, such as formaldehyde and other industrial chemicals, can induce the onset of SLE by promoting the formation of auto antibodies. This occurs after one or more of these chemicals binds to tissue in the body, forming haptens. A process that can cause the immune system to attack the body tissue to which the chemical bound, even after the chemical is no longer there.
- Excessive ultra violet light exposure is associated with the onset of SLE.
- Infections including Epstein Barr virus, and parvovirus, are sometimes associated with the onset and progression of SLE.
- Prescription Medications
- Dental Work
- Diagnostic tests for SLE include:
- Approximately 70% of people with SLE test positive for anti-double stranded DNA antibodies (meaning that their immune system has made antibodies to their own DNA).
- The anti smith antibody test is very specific for SLE.
- Approximately 50% of SLE patients have a decreased white blood cell count, and most have a decreased red blood cell count. Kidney function tests are typically also run.
Related Symptoms and Conditions
- Kidney Disease such as glomerulonephritis.
- 1/3 of people with SLE develop heart or lung complications such as:
- coronary artery disease
- valvular heart disease
- central nervous system disease.
- Orthopaedic complications such as avascular necrosis of the hip joint.
- Sjogren's syndrome
- Both Lyme Disease and HIV can present with similar symptoms as SLE. Therefore, these diseases should be ruled out before a diagnosis of SLE is made.
- Roughly 20% of SLE patients test false positive for syphilis.
- Intestinal mucus membrane hyperpermiability can contribute to SLE. When the gut is hyperpermiable, antigens and gut derived microbial toxins are able to cross from the intestines into circulation in quantities that are much higher than normal. This can cause chronic systemic inflammation.
- Impaired liver function contributes to SLE. The liver cleanses the blood by removing antigens, toxins, and large protein molecules from it. If these substances are not removed from the blood by the liver, the immune system begins to destroy them. Healthy body tissues can be targeted and damaged in this process.
There are a number of symptoms associated with SLE. How the conditions manifests is different for each person. Almost everyone with SLE has joint pain and swelling that affects the fingers, hands, wrists, and knees. In order to be classified as having SLE you typically need to have joint pain and at least three of the symptoms below:
- fatigue or sense of uneasiness or discomfort
- rashes, such as a "butterfly" rash over the cheeks and bridge of the nose, or the rash can be widespread.
- sun sensitivity and worsening of any rash in the sun
- weight loss
- hair loss
- chest pain when taking a deep breath (due to inflammation of the lining of the heart and lungs)
- fevers for no other cause
- mouth sores
- swollen lymph nodes
- dry eyes and dry mouth (due to Sjogrens syndrome)
Other symptoms depend on what part of the body is affected:
- Brain and nervous system: headaches, numbness, tingling, seizures, vision problems, personality changes, depression, cognitive dysfunction
- Digestive tract: abdominal pain, nausea, and vomiting
- Heart: abnormal heart rhythms (arrhythmias)
- Lung: coughing up blood and difficulty breathing
- Skin: patchy skin color, fingers that change color when cold (Raynaud's phenomenon)
- Hormonal: premenstrual worsening of symptoms
The goal of naturopathic treatment is to support and work in tandem with the healing power of the body and to address the causal factors of disease with individual treatment strategies. SLE is an autoimmune disease that requires a multi-faceted approach to treatment. It is common for the treatment strategy to be co-managed with a rheumatologist.
It is always advisable to work with a naturopathic doctor before engaging in any treatment plan.
Lifestyle recommendations include:
- Reduce fat and remove beef and dairy from the diet. Beef and dairy contain the amino acids phenylalanine and tyrosine, which aggravate SLE. Meat and dairy can contribute to impared kidney function in people with SLE.
- Identify food allergies and food sensitivities and remove them from the diet. Consuming foods that one is allergic or sensitive to can cause/increase intestinal hyperpermiability. This can lead to an increase in the amount of antigens entering portal circulation, and can increase the stress on the liver and the immune system, as well as contribute to autoimmunity., 
- Regularly eat non-starchy vegetables such as; celery, zucchini, summer squash, crookneck squash, green beans, broccoli, brussel sprouts, radish, asparagus, cucumber, tomato, onion, garlic, kohlrabi, and bell peppers. Non-starchy vegetables contain organic salts/electrolytes, which are necessary for proper liver function.
- Consuming vegetable broth (preferably home made with fresh vegetables) helps to replenish organic salts/electrolytes necessary for proper liver function.
- Fresh, uncooked, vegetable juice contains active enzymes that helps the liver filter chemicals and convert them to products that can be excreted from the body.
- Avoid alfalfa sprouts and alfalfa tablets, as they contain L-canavanine which can increase kidney damage, and antinuclear antibody titers.
- Supervised short-term fasting can help to ameliorate SLE. It can also shorten the early stages of glomerulonephritis.
- Ensure you drink adequate water.
The prescribing of naturopathic therapies requires the guidance of a naturopathic doctor as it depends on a number of factors including the causal factors, a person's age, prescription medications, other conditions and symptoms and overall health. It is always advisable to work with a naturopathic doctor prior to taking any natural therapies.
Naturopathic Therapies for SLE include:
- Clinical Nutritional Supplementation includes
- Vitamins such as; Vitamin B3, B5, B6, vitamin D, vitamin E, vitamin A, vitamin C.
- Minerals such as selenium.
- Amino Acids such as methionine and L-carnitine.
- Herbs such as Echinacea (Echinacea angustifolia), Milk Thistle (Silybum marianum), Dandelion (Taraxacum officinale)
Reviewed by Iva Lloyd, BScH, RPE, ND 
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Prousky Jonathan, Hoffer Abram (2008) Principles and Practices of Naturopathic Clinical Nutrition CCNM Press.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Dibner Robin, Colman Carol (1994) Lupus Handbook for Women, Simon and Schuster.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Pizzorno Joseph E, Murray Michael T (1997) A Textbook of Natural Medicine, 2nd Edition Churchill Livingstone.
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 Moore Sharon (2000) [Lupus, Alternative therapies that work] Healing Arts Press.
- ↑ 5.0 5.1 5.2 5.3 5.4 Bergner Paul (1999) Audio recording. Systemic Lupus Recorded at the Pacific North West Herbal Symposium. Tree Farm Tapes.
- ↑ PubMed Health http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001471/