Cortisol Urine Test
From Health Facts
Latest Edit: Hector 2014-03-24 (EDT)
| See Also | Lab Tests |
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Cortisol is a glucocorticoid released from the adrenal cortex. This hormone affects the metabolism of carbohydrates, proteins, and fats. It also significantly affects glucose serum levels. Cortisol can increase glucose by stimulating gluconeogenesis from glucose stores as well as inhibit the effect of insulin, thereby inhibiting glucose transport into the cells. [1],[2]
Contents
Discussion
- This test is performed in patients with suspected hypo- or hyperfunction of the adrenal gland.
- Elevated urine levels indicate elevated serum cortisol levels.
Patient Preparation
Interfering Factors
- Factors which can cause increased levels:
- pregnancy, physical and emotional stress
- Drugs: oral contraceptives, danazol, hydrocortisone, and spironolactone (Aldactone)
- Factors which can cause decreased levels:
- none noted
- Drugs: dexamethasone, ethacrynic acid, ketoconazole, and thiazides
Clinical Implications
Ranges
High levels indicate:
- Cushing's disease
- Ectopic ACTH-producing tumors
- Stress
- Cushing's syndrome
- Hyperthyroidism
- Obesity
Low levels indicate:
- Adrenal hyperplasia
- Addison's disease
- Hypopituitarism
- Hypothyroidism
Associated Tests
- ACTH stimulation test, ACTH hormone, Blood cortisol
References
- ↑ Pagana Kathleen D., Pagana Timothy J., Mosby's Manual of Diagnostic and Laboratory Tests, Mosby, Inc
- ↑ Weatherby Dicken, Ferguson Scott. Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain
