DMPS
From Health Facts
Latest Edit: Hector 2014-03-17 (EDT)
| See Also | Food Supplements |
|---|
DMPS is the common name for 2,3-dimercaptopropanol-sulfonic acid. It was developed in the Soviet Union initially, and was approved for use in Germany in the late 1970s. DMPS is not currently approved by the FDA,[1] but it is commonly used by naturopathic doctors in the chelation of heavy metals.
Uses
| Article | DMPS in the treatment of mercury toxicity, IHP, May 2008 |
|---|
DMPS is useful in chelating antimony, lead, and mercury.[1]
| Agent | Half Life | Collection Period |
| EDTA | ~1 hr | 6 - 24 hrs |
| DMPS (IV) | ~1 hr | 2 - 6 hrs |
| DMPS (oral) | ~9 hrs | 6 - 9 hrs |
| DMSA | ~4 hrs | 6 - 9 hrs |
Prescribing considerations
- Adjuncts
- Route of Administration
- DMPS can be administered in oral, intramuscular, or intravenous routes.[1]
Safety
- DMPS is regularly used in place of a similar chelating agent, British Anti-Lewisite (BAL) due to its better safety profile. Studies involving oral doses of 300mg have demonstrated DMPS to be safe. Doses as high as 3mg/kg have been investigated intravenously. This large IV dose caused a drop in blood pressure in two patients in the trial without any other adverse effects.[3]
- DMPS is water-soluble and is excreted primarily by the kidneys.
- Most adverse affects to DMPS are limited to allergic skin reactions, mucous membrane reaction, and elevation in body temperature.[1]
- Case reports of adverse reactions to DMPS do exist. Chelation therapy with DMPS to treat lead exposure was implicated in a bullous skin reaction in a German man.[4]There is also a case report of Stevens-Johnson syndrome in a boy undergoing DMPS therapy to treat elevated mercury levels. SJS resolved gradually after stopping DMPS therapy.[5] About 5 to 10% of people are prone to skin reactions that generally subside within 3 to 5 days.
Efficacy
- Animal studies suggest DMPS is equal to or better than both DMSA and BAL in arsenic chelation. DMPS has been associated with recovery from peripheral neuropathy associated with arsenic exposure.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Hall AH, Shannon MW (2007) Shannon: Haddad and Winchester’s Clinical Management of Poisoning and Drug Overdose 4th ed Chap 75 Other Heavy Metals Saunders.
- ↑ Flora SJ, Mittal M, Mehta A (2008) Heavy metal induced oxidative stress and its possible reversal by chelation therapy Indian J Med Res 128(4):501-23
- ↑ 3.0 3.1 Bernhoft RA (2011) Mercury Toxicity and Treatment: A Review of the Literature J Environ Public Health. [published online 2011 Dec 22 doi: 10.1155/2012/460508]
- ↑ Storim J, Stoevesandt J, Anders D, Kneitz H, Brocker EB, Tratumann A (2011) Dithiols as chelators. A cause of bullous skin reactions Hautaratz 62(3):215-8
- ↑ Van der Linde AA, Pillen S, Gerritis GP, Bouwes Bavinck JN (2008) Stevens-Johnson syndrome in a child with chronic mercury exposure and 2,3-dimercaptopropane-1 sulfate (DMPS) therapy Clin Toxicol 46(5):479-81
