Luteinizing hormone (LH)
From Health Facts
Latest Edit: Hector 2014-03-24 (EDT)
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- Luteinizing hormone is also known as Interstitial Cell Stimulating Hormone (ICSH)
- LH is produced in the anterior pituitary gland in reponse to stimulation by gonadotropin-releasing hormone (GNRH). Control of LH production is a complex system involving hormones produced by the ovaries or testes, the pituitary and the hypothalamus.
- High levels of LH (and FSH) at mid-cycle triggers ovulation for women.
- LH stimulates the ovaries to produce steroids, primarily estradiol.
- In men, LH stimulates a Leydig cells which reside in the testes to produce testosterone.
- Indications for assessing LH levels include:
- difficulty getting pregnant, irregular or heavy menstrual periods
- symptoms of pituitary or hypothalamic disorders
- symptoms of ovarian or testicular disease
- delayed or early childhood sexual maturation
- No fasting required.
- LH can be measured in blood, or urine
- Factors which can cause increased levels
- radiation therapy
- Medications such as cimetidine, digitalis, levodopa, anticonvulsants, clomiphene, naloxone, and spironalactone
- Factors which can cause decreased levels
High levels indicate:
- primary ovarian failure
- primary testicular failure
Low levels indicate:
- Secondary ovarian failure
- Pagana Kathleen D, Pagana Timothy J (2006) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby.