Methlysulphonylmethane (MSM)

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Latest Edit: Hector 2014-03-17 (EDT)

See Also Food Supplements

Methylsufonylmethane or MSM is a sulfur-containing molecule and the oxidized form of the anti-inflammatory compound dimethyl sulfoxide (DMSO).[1]

MSM is also known as DMSO2, methyl sulfone, and dimethyl sulfone.

Food Sources

MSM is a chemical found in plants, animals, and humans.


MSM is primary used to treat the following conditions:

Prescribing Considerations

The recommended dosages have not yet been established. To determine what your specific requirements are talk to your naturopathic doctor or other trained medical professional.

  • Adult: The general dosage is about 500 mg three to four times a day.


Methlysulphonylmethane (MSM) is generally considered safe.

  • High doses of MSM may cause diarrhea or nausea. These effects are typically short-lived.
  • Allergies to MSM can exist and may show up as headaches, gastrointestinal irritation and skin rashes.
  • Pregnancy and Breastfeeding
  • There are no sufficient studies to determine the safety of MSM when pregnant. It is best avoided during these times.


  1. 1.0 1.1 Gaby AR (2011) Nutritional Medicine. Fritz Perlberg Publishing.