Apolipoprotein A-1

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Latest Edit: Hector 2014-03-21 (EDT)

See Also Lab Tests

Apolipoproteins are a protein component of lipoprotein complexes. Apolipoprotein A-1 (Apo A) is the major component of HDL, while Apolipoprotein B is the major component of LDL.[1],[2]


Apolipoprotein A1 is greater predictor for lower incidence of cardiovascular disease than HDL alone. Apolipoprotein A1 activates the enzymes that load cholesterol from the tissues into HDL and allows HDL to effectively get rid of the excess cholesterol at the tissue level. Deficiencies in apolipoprotein A1 are associated with increased risk of cardiovascular disease as the cholesterol is not transported back to the liver.

Patient Preparation

  • Patient must fast for 12- 14 hours before testing. Water is permitted.
  • Smoking is prohibited.
  • Factors which can cause increased levels:
  • physical exercise
  • Drugs: carbamazepine, estrogens, ehtanol, lovastatin, niacin, oral contraceptives, phenobarbital, pravastatin, and simvastatin
  • Factors which can cause decreased levels:

Clinical Implications

  • High levels indicate:
  • Low levels indicate:

Associated Tests

The tests that are often run in conjunction with Apo A-1 includes Apolipoprotein B, Triglycerides, cholesterol, LDL, HDL, VLDL, Uric acid, Lipid electrophoresis, RBC, HCT, and HGB


  1. Pagana Kathleen D, Pagana Timothy J, (1998) Mosby's Manual of Diagnostic and Laboratory Tests, Mosby, Inc
  2. Weatherby Dicken, Ferguson Scott (2002) Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective, Bear Mountain