Inositol
| See Also | Food Supplements |
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Inositol is unofficially part of the complex of B vitamins and functions similarly to choline. Inositol can be found in cell membranes where it exists in the form known as phosphatidylinositol. Although it is not considered an essential nutrient in the human diet, it does have many benefits. First, it displays a lipotropic effect meaning that it helps to export fat from the liver and aids in proper lipid metabolism. This is critical for optimal health and proper functioning of the liver. Second, inositol is also important for the proper functioning of nerves, the brain, and muscles. Third, inositol is found as a fiber compound known as phytic acid. This compound is known to exert anticancer effects and may be why high fiber diets are protective against cancer.[1]
| Article | Phospholipids choline, serine, and inositol, IHP, [1], September 2011 |
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Contents
Food Sources
Inositol is found in food sources mainly as a fiber component known as phytic acid (inositol phosphate). Intestinal bacteria release inositol from phytic acid. The form available in animal sources is known as myo-inositol.
- Good Plant Sources include: citrus fruits, whole grains, nuts and seeds, and legumes.
Uses
The following is a list of the primary uses for inositol. [1]
- Liver Disorders: Inositol is used as a liptropic factor used to treat a variety of liver disorders.
- Depression and Panic Attacks: Inositol is essential for the proper functioning of serotonin and acetylcholine amongst other neurotransmitters. Low levels of brain inositol may lead to depression and supplementation with inositol has shown positive antidepressant effects in several studies. Studies have also shown positive results in terms of treatment of panic disorders.
- Diabetes: Inositol has shown some positive results in treating diabetic neuropathy. Supplementation of inositol possibly improves conduction velocities in nerves and may be considered for a comprehensive treatment of diabetes but should not be used alone.
Assessment Procedure
Blood and CSF inositol levels have been used in the laboratory setting but are not in clinical use.[2]
Prescribing Considerations
The recommended dosages have not yet been established. To determine what your specific requirements are talk to your naturopathic doctor or other trained medical professional.
- Inositol is available commercially as inositol monophosphate.[1]
Safety
Inositol is generally considered safe and no toxic effects have been reported with supplementation.[2]
- Pregnancy and Breastfeeding
- Inositol may effect oxytocin and uterine contractions during pregnancy. Evidence is lacking regarding adverse effects to fetal development during pregnancy or to breast-fed infants. Caution is advised.
- Contraindications
- Attention deficit-hyperactivity disorder, chronic renal failure, schizophrenia and pregnancy.
- Precautions
- Use of inositol in individuals with bipolar disorder may trigger manic episodes; use only myo-inositol under medical supervision.
- Drug Interactions:[2]
- Supportive or Beneficial
- Lithium depletes brain stores of inositol. Co-administration may reduce adverse effects associated with long-term lithium therapy especially psoriasis and polydipsia-polyuria. Clinical trials are warranted.
- Nutrient Interactions[2]
References
- ↑ 1.0 1.1 1.2 Murray Michael T (1996) Encyclopedia of Nutritional Supplements, The Essential Guide for Improving Your Health Naturally, Prima Publishing.
- ↑ 2.0 2.1 2.2 2.3 Stargrove Mitchell Bebell, Treasure Jonathan, McKee Dwight L (2008) Herb, Nutrient, and Drug Interactions, Clinical Implications and Therapeutic Strategies. Mosby
